Mood Probiotic

During the clinical trials outlined by the methods section the probiotics were microencapsulated(ME). This has proposed up to 10x the survivability rate of various strains. Is this formulation microencapsulated? Alan

Hi Alan – yes, the clinical studies were performed with the microencapsulated version of the strains. The reason for microencapsulation was not solely to protect the strains from stomach acid, but rather to provide ‘on-the-go’ convenience in a sachet. There is a minor level of stomach acid protection from the microencapsulation, but this effect is small and temporary. But all in all, participants in the studies took a dose of 3 billion cfu/daily intake of both strains in a specific ratio. We have kept same dosage (3 billion cfu/capsule) with same ratio in the capsule, and it is recommended to take the formula during meals, to ensure better survival of the strains (the meal plays a buffering role). Taking one version or the other, you will still ingest the same dose of bacteria. Additionally, there are 7 in vivo studies to better understand the modes of action of the formula and strains (as per attached document) and all studies were performed with non-microencapsulated strains. The end-result (health outcome) were the same. - InnovixLabs Customer Service

What is the recommendation regarding taking Mood Probiotics with other probiotics (such as from Udo’s Choice – 90 billion, etc)? Janice

Hi Janice – you can take the Mood Probiotic along with other probiotics products. InnovixLabs Magnesium, Omega-3, and Prebiotic fiber all support mood health as well. - InnovixLabs Customer Service

Resistance to stomac acid is a critical cretaria for choosing a good probiotic. Are the probiotic strain used in mood probiotic (Lactobacillus helveticus Rosell-52ND and Bifidobacterium longum Rosell-175) stomac acid resistant strains? Why is it not in delayed release capsule to further protect it from stomac acid until it reaches the intestines. Even when taken with a meal, what percentage of the probiotic do you think will survive stomac acidity. Simeon

Hi Simeon – the two Rosell strains are licensed from the Rosell Institute (Lallemand) based on their research and published clinical studies. In their studies (which showed significant improvement in mood issues), they used the strains without additional stomach acid protection. The strains have some natural built-in acid resistance. However, we agree with you that if there was additional acid protection in the form of acid-resistant capsules etc., the results may possibly have been even better. Since the clinical studies DID NOT use additional acid-protection, we are required use the same delivery formats used in the clinical study if we wish to make the same health claims. To your question about what percent survives stomach acid if taken with a meal, we do not have a clear answer, but ‘several million’ appears to be accurate. It is possible that the health outcome noticed in the clinical studies are due to just the millions (rather than the billions) of colonies. It is also possible that once established in the gut, these bacteria can be ‘fed’ or ‘fertilized’ with prebiotic fibers into not just billion but trillions in very short order. We do not have a clinical study to show that these two strains taken in combination with prebiotic fibers demonstrate an even greater health benefit. So, it remains a hypothesis. Having said that, our knowledge of the microbiome is in its infancy. There is new evidence that even small DNA fragments from dead strains are capable of influencing health outcomes. This is emerging science and we are staying tuned. - InnovixLabs Customer Service

Hi. On Amazon the photo of the box says 15 billion. On here it shows 3 billion. Which is it? Joe

Hi Joe – both numbers are on the current package. There will be a minimum of 15 billion live cultures at time of manufacture and as the product naturally ages, the live culture count will naturally lower to 3 billion at time of expiration. The health claims attached to the product are based on 3 billion live cultures. - InnovixLabs Customer Service

You say you are using palm oil. As an animal activist I have obvious concerns about the use of palm oil unless it is harvested in a way that causes no harm to animals or the environment (Dr. Bronners products are a great example of humane practices for the use of palm oil.) Where do you harvest your palm oil and is it harvested in a way that protects the animals and the environment? C

Hi C – this is an issue near and dear to our company founder. He’s an environmentalist and has spent a lot of time making sure that the ingredient we use are gentle on the environment. We use certified sustainable palm products, but even when no harm is done to wildlife, palm oil culture is a monoculture (one species) and lacks biodiversity to sustain multitude of creatures. So we are investigating other, friendlier ingredients. - InnovixLabs Customer Service

In reply to InnovixLabs. According to Examine.com, they say: “Taking a probiotic supplement made up of multiple strains of bacteria can have increased effectiveness through an additive or synergistic effect of the individual strains, compared with mono-species supplements. However, some probiotics may work in an antagonistic manner, so combinations of strains should be studied both individually and in combination before creating a multispecies product.” — So how are we to know for sure if taking other probiotic supplements alongside Mood Probiotics will be beneficial or worse? Joseph

Hi Joseph – if there is any antagonistic behavior (one species thrives in the capsule while some others perish) between strains, it is usually in the capsule. Once the capsule has been consumed, the strains have to contend with hundreds of species in our gut. Within the capsule itself, the strains in Mood Probiotic are not known to be antagonistic towards each other. - InnovixLabs Customer Service

Is this product CFUC colony forming units?

Hi Tom, yes, the product is designed to have 3 billion CFU (colony forming units) by the expiration date, assuming it is stored according to instructions. It is, however, formulated with 15 billion CFU...or put another way, that's how much is put into each capsule at time of manufacture. This number will gradually decrease from 15 billion to 3 billion over the life of the product.  It is normal for probiotic products to decrease in potency over time. This is why the products are overfilled (also known as overage) to provide the minimum effective dose used in clinical studies.